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目的研究不同部位损伤对SD大鼠动眼神经功能修复的影响及可能机制。方法经幕下和眶上裂切断和修复动眼神经,术后通过前庭眼反射评估眼外肌在垂直和水平方向的恢复程度,经右侧上直肌注射辣根过氧化酶,逆行追踪中脑动眼神经核团内神经元分布,进行动眼神经解剖学和组织学研究。结果经眶上裂干预动眼神经的实验组大鼠新生神经纤维对眼外肌支配的特异性较高,其眼外肌功能恢复程度明显优于经幕下干预动眼神经的实验组大鼠。结论动眼神经损伤部位距离眼外肌越近,最终的神经功能恢复就越好,这与再生神经纤维通过损伤部位时的迷行程度相关。
Objective To study the effect of different parts of injury on oculomotor nerve function in SD rats and its possible mechanism. Methods The oculomotor nerve was cut off and repaired by supratentorial and supraorbital fissure. The degree of recovery of the extraocular muscle in both vertical and horizontal directions was evaluated by vestibular refraction after surgery. Horseradish peroxidase The distribution of neurons in the oculomotor nuclei is studied by oculomotor nerve anatomy and histology. Results The experimental group of superior oculomotor nerve fibers through the superior orbital fissure preconditioned nerve fibers had a higher specificity to the extraocular muscles. The degree of extraocular muscle function recovery was superior to that of the experimental group. Conclusions The closer the oculomotor nerve injury site is to the extraocular muscles, the better the final neurological function recovery, which is related to the degree of vagusia when the regenerated nerve fibers pass through the injury site.