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口服常规剂量苯妥英钠致血清苯妥英钠浓度增高多有报道,但达60mg/L以上者少见,现报道2例如下:病历摘要例1。女,23岁,体重47kg,1年前外伤后始有发作性意识丧失,抽搐,1个月前开始服苯妥英钠0.1,一日二次,服药后2周出现头晕,行走不稳,近2日症状加重,卧床不起而来诊。查体:意识清,反应迟钝,不能对答,双眼水平性眼震,四肢肌力4级,指鼻、跟膝胫试验不准,病理征阴性。血清苯妥英钠浓度66.52mg/L.停用苯妥英钠,补液等治疗3天,能讲话,头晕减轻,5天可下床活动,1周眼震消失,血清苯妥英钠浓度降至18.37mg/L。例2。男,20岁,体重56kg,4周前出现发作性意识不清,抽搐,口吐白沫,诊断为病毒性脑炎,继发
Oral conventional doses of phenytoin sodium serum phenytoin sodium concentration increased more than reported, but up to 60mg / L or more are rare, are reported in 2 cases as follows: Case Summary 1. Female, 23 years old, weight 47kg, 1 year ago, the onset of traumatic episodes of seizure loss of consciousness, convulsions, a month ago began taking phenytoin 0.1, twice a day, 2 weeks after taking the medication appear dizzy, unstable walking, nearly 2 Day symptoms worsened, bedridden come to the clinic. Physical examination: clear consciousness, unresponsive, can not answer, eyes horizontal nystagmus, limb muscle strength 4, finger nose, knee with knee test is not allowed, pathology sign negative. Serum phenytoin concentration 66.52mg / L. Stop phenytoin sodium, rehydration and other treatment for 3 days, to speak, reduce dizziness, 5 days to get out of bed activity, 1 week nystagia disappear, serum phenytoin sodium concentration decreased to 18.37mg / L. Example 2. Male, 20 years old, weight 56kg, 4 weeks ago Episodic consciousness, convulsions, foaming at the mouth, diagnosis of viral encephalitis, secondary