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目的:探讨Bag-1蛋白在正常胃黏膜和胃腺癌组织中的表达,及其与胃腺癌临床病理特征之间的关系。方法:采用免疫组织化学法,分别检测20例正常胃黏膜、60例胃腺癌组织标本中Bag-1蛋白的表达。结果:Bag-1蛋白在胃腺癌组织中表达阳性率显著高于正常胃黏膜组织(P<0.05),并且其表达水平与肿瘤分化程度有关。结论:Bag-1基因与胃腺癌细胞的凋亡有关,其高表达在胃腺癌的发生发展过程中发挥重要作用。
Objective: To investigate the expression of Bag-1 protein in normal gastric mucosa and gastric adenocarcinoma and its relationship with clinicopathological features of gastric adenocarcinoma. Methods: Immunohistochemical method was used to detect the expression of Bag-1 protein in 20 cases of normal gastric mucosa and 60 cases of gastric adenocarcinoma respectively. Results: The positive rate of Bag-1 protein in gastric adenocarcinoma was significantly higher than that in normal gastric mucosa (P <0.05), and the expression level of Bag-1 was related to the degree of tumor differentiation. Conclusion: Bag-1 gene is involved in the apoptosis of gastric adenocarcinoma cells. The high expression of Bag-1 gene plays an important role in the development of gastric adenocarcinoma.