瘦素是近年发现的一种与肥胖症有关的激素。它通过与下丘脑特异受体结合 ,发挥维持机体正常体重的功能。同时瘦素对胰岛素分泌及胰岛素的外周作用亦存在影响 ,但结果不一 ,对其作用机制尚少有报道。我们研究瘦素对胰岛素分泌的急性与慢性影响 ,并通过观察细胞内游离钙、葡萄糖 Leptin is an obesity-related hormone found in recent years. It binds to specific receptors in the hypothalamus and functions to maintain normal body weight. Leptin at the same time on insulin secretion and insulin peripheral effects also have an impact, but the results vary, its mechanism of action is still rarely reported. We studied the acute and chronic effects of leptin on insulin secretion, and by observing intracellular free calcium, glucose