先证者(Ⅳ_8),男,1岁半,汉族,1988年11月11日来我院就诊。8个月会坐,1岁能扶站,至今不会独走。智力发育及语言能力明显低下,对外界反应差。体检:脸稍长,方额,左眼轻度内斜,上腭不高,招风耳,睾丸容积为2.04cm~3,双手通贯掌,atd角均55°。先证者之兄(Ⅳ_7),12岁,智力低下,4岁能独走,5岁会叫爸妈,至今未读书,不会算数。多动,只 Probate (Ⅳ_8), male, 1 year and a half, Han nationality, November 11, 1988 came to our hospital. 8 months will sit, 1-year-old can help station, so far will not be alone. Mental development and language skills were significantly lower, poor response to the outside world. Physical examination: face a little longer, square, the left eye was mildly oblique, the palate is not high, Zhao Feng ears, testicular volume 2.04cm ~ 3, hands pass palm, atd angle 55 °. The proband’s brother (Ⅳ_7), 12 years old, mental retardation, 4-year-old can walk alone, 5-year-old will be called parents, has not read books, will not count. Hyperactivity, only