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本文从遗传学和脑损伤两个方面探讨了癫痫的发病原因。家族史资料表明,癫痫发病存在家族聚集性和遗传易患性,且各发作类型均有之。家系脑电图发现癫痫一级亲属痫波携带率(28%～52%)显著高于对照(1.93%),说明脑神经元膜电位不稳定,是本病遗传机制的脑电学表现。染色体所见脆性增高也与癫痫遗传密切相关。Ca~(2+)-ATP酶研究显示,敏感型癫痫模型小鼠声刺激发作率显著高于对照,而脑组织Ca~(2+)-ATP酶活性则显著低于对照,提示脑组织Ca~(2+)-ATP酶活性低下,可能是癫痫遗传机制的生化学表现。认为癫痫发病主要是由遗传易患性和脑损伤决定的。
This article from the genetics and brain injury in two aspects of the pathogenesis of epilepsy. Family history data show that there is familial aggregation and genetic predisposition to epilepsy, and the types of attacks are. Family EEG found that first-degree relatives of epilepsy carrier rate (28% ~ 52%) was significantly higher than the control (1.93%), indicating that the neuronal membrane potential instability is the genetic mechanism of the EEG brain electrical performance. Chromosomes see increased brittleness is also closely related with the genetic epilepsy. The study of Ca ~ (2 +) - ATPase showed that the incidence of sonic stimulation in mice with sensitive epilepsy was significantly higher than that of the control, while the activity of Ca ~ (2 +) - ATPase in brain was significantly lower than that of the control The low activity of ~ (2 +) - ATPase may be the biochemical manifestation of the genetic mechanism of epilepsy. The incidence of epilepsy is mainly determined by genetic predisposition and brain damage.