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目的建立11种光引发剂类化合物食品用纸杯特定迁移量的气相色谱-串联质谱(gas chromatographytandem mass spectrometry,GC-MS/MS)检测方法。方法食品模拟物中的光引发剂类化合物经反相固相萃取柱富集净化后,采用中等级性的DM-17MS气相色谱柱进行分离;采用三重四极质谱的多反应监测模式(multiple reaction monitoring,MRM)对化合物进行定量测定。结果本方法可在17 min内完成11种目标化合物的色谱分离。11种光引发剂在低、中、高3个添加水平的回收率在65.0%~119.8%范围内,相对标准偏差为1.2%~10.6%(n=6),方法检出限为1~7μg/L,定量限为2~20μg/L。结论该方法灵敏度高,定量准确,适用于食品模拟物中光引发剂类物质特定迁移量的测定。
Objective To establish a gas chromatography-tandem mass spectrometry (GC-MS / MS) method for the determination of eleven photoinitiator specific food paper cups. Methods The photoinitiators in the food simulants were separated and purified by reversed-phase solid-phase extraction (SPE) column, and were separated by medium-grade DM-17MS gas chromatographic column. The multiple reaction monitoring was performed by triple quadrupole mass spectrometry monitoring, MRM) for the quantitative determination of compounds. Results The method can complete the chromatographic separation of 11 target compounds in 17 min. The recoveries of 11 photoinitiators at low, medium and high levels were in the range of 65.0% ~ 119.8% with relative standard deviations of 1.2% ~ 10.6% (n = 6). The detection limits of these methods were 1 ~ 7μg / L, the limit of quantification is 2 ~ 20μg / L. Conclusion The method has high sensitivity and quantitative accuracy and is suitable for the determination of specific migration amount of photoinitiators in food simulants.