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在外周压力感受器去神经支配的大鼠上 ,用Fos蛋白和酪氨酸羟化酶 (TH)的双重免疫组化方法 ,研究辣椒素的效应是否通过激活脑干核团内儿茶酚胺能神经元而诱发。结果显示 ,颈动脉注射辣椒素诱发脑干中最后区 (AP)、孤束核 (NTS)、巨细胞旁外侧核 (PGL)和蓝斑 (LC)等多个部位出现大量Fos样免疫反应(FLI)神经元和双标神经元 ,辣椒素受体阻断剂钌红 (RR)或NMDA受体阻断剂MK 80 1可明显减弱此效应。以上结果表明 ,辣椒素的兴奋效应通过激活儿茶酚胺能神经元而诱发 ,辣椒素受体和 / (或 )谷氨酸介导这一效应
The double immunohistochemistry of Fos protein and tyrosine hydroxylase (TH) was used to investigate whether the effect of capsaicin was activated by activation of catecholaminergic neurons in the brainstem nucleus in a denervated peripheral nociceptin rat Induced. The results showed that there were a large number of Fos-like immunoreactions in the carotid artery in the brainstem at the apical area (AP), nucleus tractus solitarius (NTS), the extracellular lateral nucleus (PGL) and the locus coeruleus (LC) FLI) neurons and double-labeled neurons, the capsaicin receptor blocker ruthenium red (RR) or the NMDA receptor blocker MK 80 1 significantly attenuated this effect. The above results indicate that the excitatory effect of capsaicin is induced by activation of catecholaminergic neurons, which is mediated by capsaicin receptor and / or glutamate