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最近研究发现 ,钾通道在调节血管平滑肌生长方面起重要作用 ,故成为当今研究的一大焦点。钾通道表达和活性的巨大变化可引起细胞电生理性能的显著改变及血管平滑肌细胞的增生 ( SMCs)。这些发现表明 ,钾通道功能改变对平滑肌细胞增生起重要作用。但是 ,钾通道活性改变对细胞生长的影响机制尚不清楚。钙离子信号传导的空间与时间的明显差别主要与钾通道调节所致的急性电性能改变有关。因此 ,钾通道功能改变可能代表了一种普遍机制 ,即钙信号靶向的基因表达与细胞生长的激活作用。由于平滑肌增生是许多心血管疾病和临床病理变化的基础 ,明确钾通道在平滑肌细胞增生中所起的重要作用 ,可以为调节血管增生性疾病的靶向治疗提供一个新的突破口。
Recent studies have found that potassium channels play an important role in the regulation of vascular smooth muscle growth and have become a major focus of current research. The dramatic changes in potassium channel expression and activity can cause significant changes in cellular electrophysiological properties and vascular smooth muscle cell proliferation (SMCs). These findings indicate that changes in potassium channel function play an important role in smooth muscle cell proliferation. However, the mechanism by which potassium channel activity changes affect cell growth remains unclear. Significant differences between calcium and signal transduction space and time are mainly associated with changes in acute electrical properties caused by potassium channel modulation. Thus, changes in potassium channel function may represent a general mechanism by which calcium signaling targets gene expression and cell growth activation. As smooth muscle proliferation is the basis of many cardiovascular diseases and clinicopathological changes, it is clear that potassium channel plays an important role in the proliferation of smooth muscle cells, which can provide a new breakthrough for the targeted therapy of vascular proliferative diseases.