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载脂蛋白(apolipoprotein,apo)是脂蛋白中的蛋白质部分,在脂蛋白的运输和代谢过程中具有重要作用。apoA-1和apoB-100分别为HDL和LDL中的主要蛋白质,其定量测定已被用于评价动脉粥样硬化性疾病(AS)、监测AS治疗效果等方面。比较研究已证实,apoA-1/apoB-100比值在预测AS危险中最有价值。目前对apoA-1和apoB-100的定量测定已发展了各种免疫测定方法,诸如放免测定(Radioimmuno-assay,RIA),电免疫测定(Electroimmuno-assay,EIA,又称火箭电泳),圆周免疫扩散
Apolipoprotein (apo) is a protein part of lipoproteins that plays an important role in the transport and metabolism of lipoproteins. apoA-1 and apoB-100 are major proteins in HDL and LDL, respectively. The quantitative determination of apoA-1 and apoB-100 has been used to evaluate atherosclerotic disease (AS) and monitor the therapeutic effect of AS. Comparative studies have shown that apoA-1 / apoB-100 ratio is most valuable in predicting AS risk. At present, a variety of immunoassay methods have been developed for the quantitative determination of apoA-1 and apoB-100, such as radioimmuno-assay (RIA), electroimmuno-assay (EIA) diffusion