Objective: To explore the effect of Xuefu Zhuyu Decoction (XZD) on molecular expression of platelets glycoprotein Ⅱb/Ⅲa complex (GP Ⅱb/Ⅲa) and thrombomodulin (TM) of human umbilical vein endothelial cells.Methods: Platelets and human umbilical vein endothelial cells were incubated with XZD of different concentration. GPⅡb/Ⅲa and TM were evaluated by radioimmunoassay.Results: XZD in 40 mg/ml and 80 mg/ml could obviously inhibit the adenosine diphosphate induced GPⅡb/Ⅲa complex expression, the molecular number being 52900±8445 and 52095±6345 respectively, and there was significant difference as comparing with that in the control group ( P <0.05, P <0.01). But XZD didn’t show any influence on the molecular expression of TM in human umbilical vein endothelial cells.Conclusion: XZD could inhibit the adenosine diphosphate induced activation of platete through blocking the exposure of GPⅡb/Ⅲa complex. Objective: To explore the effect of Xuefu Zhuyu Decoction (XZD) on molecular expression of platelets glycoprotein IIb/IIIa complex (GP IIb/IIIa) and thrombomodulin (TM) of human umbilical mediolateral endothelial cells. Methods: Platelets and human umbilical vein endothelial cells Were incubated with XZD of different concentration. GPIIb/IIIa and TM were evaluated by radioimmunoassay.Results: XZD in 40 mg/ml and 80 mg/ml could obviously inhibit the adenosine diphosphateindependent GPIIb/IIIa complex expression, the molecular number being 52900± 8445 and 52095±6345 respectively, and there was significant difference as comparing with that in the control group ( P <0.05, P <0.01). But XZD didn’t show any influence on the molecular expression of TM in human umbilical vein endothelial cells .Conclusion: XZD could inhibit the adenosine diphosphateinduced activation of platete through blocking the exposure of GPIIb/IIIa complex.