氨基糖甙类抗生素临床应用较为广泛,但有明显的肾毒副作用,严重者可发生少见的急性肾小管坏死及肾功能衰竭。死亡病例报道甚少,现将我们遇到的2例报告如下。例1 白某某,男,3岁,住院号54569。1983年8月19日入院,8月25日死亡。于入院前10天始发烧,脓血便,每日10余次,伴口渴,尿少。某公社医院以“菌痢”治疗,肌注庆大霉素每次8万u,卡那霉素每次0.5克,每日各 Aminoglycoside antibiotics are widely used, but there are obvious side effects of nephrotoxicity, severe acute tubular necrosis and renal failure may occur rare. There are few reports of deaths, and now we report the following two cases. Example 1 Bai Moumou, male, 3 years old, hospital number 54569. Admitted to hospital on August 19, 1983, died August 25. 10 days before admission, fever, pus and blood stool, more than 10 times a day, with thirst, oliguria. A commune hospital to “bacillary dysentery” treatment, intramuscular injection of gentamicin each 80,000 u, kanamycin each 0.5 grams, each day