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目的探讨局部外用噻吗洛尔滴眼液治疗浅表型婴幼儿血管瘤的疗效及安全性。方法将50例浅表型婴幼儿血管瘤患儿随机分为两组,每组各25例,试验组给予0.5%噻吗洛尔滴眼液30μL·cm~(-2),均匀涂于血管瘤的表面,每日2次;对照组给予5%咪喹莫特乳膏,均匀涂抹于血管瘤表面,每周3次,疗程均为3~6月。观察血管瘤颜色、厚度、面积变化并评分,记录不良反应发生情况,比较两组疗效。结果两组均完成24例。治疗后,试验组有效率为88%(21/24),对照组为71%(17/24),两组疗效比较差异显著(P<0.05)。试验组起效时间为(8.2±4.3)d,短于对照组[(12.3±5.2)d,P<0.05]。试验组病灶总评分为(5.7±1.2)分,对照组为(4.1±1.1)分,组间差异显著(P<0.05)。两组均未见明显不良反应发生。结论噻吗洛尔滴眼液治疗婴幼儿浅表型血管瘤的疗效好、安全性高,值得在临床推广应用。
Objective To investigate the efficacy and safety of topical timolol eye drops in the treatment of superficial infantile hemangiomas. Methods Fifty cases of infantile hemangiomas of superficial infantile infants were randomly divided into two groups with 25 cases in each group. The experimental group was given 0.5% timolol eye drops 30μL · cm ~ (-2) The tumor surface, 2 times a day; the control group was given 5% imiquimod cream, evenly applied to the surface of hemangioma, 3 times a week, treatment were 3 to 6 months. The changes of hemangiomas’ color, thickness and area were observed and scored. The incidence of adverse reactions was recorded. The curative effect was compared between the two groups. Results Both groups were completed in 24 cases. After treatment, the effective rate was 88% (21/24) in the experimental group and 71% (17/24) in the control group, with significant difference between the two groups (P <0.05). The onset time of the experimental group was (8.2 ± 4.3) d, shorter than that of the control group [(12.3 ± 5.2) d, P <0.05]. The test group had a total score of (5.7 ± 1.2) points and a score of (4.1 ± 1.1) points in the control group, with significant differences (P <0.05). No obvious adverse reactions occurred in both groups. Conclusion Timolol eye drops treatment of superficial hemangiomas in infants and children good effect, high safety, it is worth in the clinical application.