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研究钙离子导体Ａ２３１８７（１μｍｏｌ／Ｌ）、凝血酶（２ｕ／ｍｌ）、腺苷二磷酸（ＡＤＰ，２００μｍｏｌ／Ｌ）激活血小板的超微结构和颗粒数的变化。采用电子显微术和颗粒数密度（Ｎｖ）计量法。结果：激活的血小板有变形，包括伪足生成，颗粒移向中央区，微管解聚，分泌颗粒的胞吐现象及分泌颗粒减少等一系列反应，３种激动剂所引起的形态变化并无明显差异。小剂量Ａ２３１８７引起αＧ和ｄＧ的数密度分别下降５２．８８％和３６．０２％，两者差异显著（Ｐ＜０．０１）。用量大的ＡＤＰ对两种颗粒促释放的影响则无差异。结论：激动剂作用较弱时αＧ较ｄＧ更易释放。
To study the changes of ultrastructure and number of particles activated by calcium ion conductor A23187 (1μmol / L), thrombin (2u / ml) and adenosine diphosphate (ADP, 200μmol / L) Electron microscopy and particle number density (Nv) metrology were used. Results: The activated platelets were deformed, including the formation of pseudopods, the migration of the particles to the central region, the depolymerization of microtubules, the exocytosis of secretory granules and the reduction of secretory granules. The morphological changes caused by the three agonists did not Significant differences. A23187 caused a small dose of αG and dG number density decreased 52.88% and 36.02%, the difference between the two significant (P <0.01). There was no difference in the effect of the large amount of ADP on the two kinds of particles to promote release. CONCLUSION: αG is more easily released than dG when the agonist is weaker.