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Fas抗原，又称APO-1或CD95，是一种319个氨基酸组成的Ⅰ型跨膜糖蛋白，属于肿瘤坏死因子和神经生长因子受体超家庭成员。Fas抗原表达于各种细胞，如活化的T，B细胞，NK细胞，胸腺细胞，恶性的T、B细胞，成纤维细胞等。人与小鼠的Fas基因分别定位于第10号及第19号染色体。Fas抗原的天然配体是一种Ⅱ型跨膜糖蛋白，属于肿瘤坏死因子家族成员，其主要分布于活化的T细胞。Fas抗原及配体系统异常的两种小鼠Lpr与gld表现自身免疫病理变化。抗Fas抗体或表达Fas配体的细胞交联Fas抗原，可诱导细胞凋亡，提示Fas／Apo──1抗原是细胞凋亡过程中重要信号传递分子。Fas抗原诱导的细胞凋亡在调控免疫细胞的发育，增殖及免疫应答中起主导作用。已经证实Fas系统在T细胞的发育，细胞毒作用及细胞毒性T介导自身免疫病中发挥重要作用。而且抗Fas抗体或Fas配体可诱导肿瘤细胞凋亡。Fas抗原系统的研究将有助于阐明自身免疫病发病机制，开辟肿瘤治疗的新途径。
Fas antigen, also known as APO-1 or CD95, is a 319-amino acid type I transmembrane glycoprotein belonging to the families of tumor necrosis factor and nerve growth factor receptor superfamily. Fas antigen is expressed in various cells, such as activated T, B cells, NK cells, thymocytes, malignant T, B cells, fibroblasts and the like. The Fas and Fas genes of human and mouse are located on chromosomes 10 and 19, respectively. The natural ligand for the Fas antigen is a Type II transmembrane glycoprotein, a member of the tumor necrosis factor family, which is found primarily in activated T cells. Both Lpr and gld mice with Fas antigen and ligand system abnormalities showed autoimmune pathological changes. Anti-Fas antibody or Fas ligand-expressing cells cross-linking Fas antigen can induce apoptosis, suggesting that Fas / Apo ─ ─ 1 antigen is an important signal transduction molecule in the process of apoptosis. Fas antigen-induced apoptosis plays a leading role in the regulation of immune cell development, proliferation and immune response. Fas system has been shown to play an important role in T cell development, cytotoxicity and cytotoxic T mediated autoimmune disease. Moreover, anti-Fas antibody or Fas ligand can induce tumor cell apoptosis. Fas antigen system research will help clarify the pathogenesis of autoimmune diseases, open up new avenues of cancer treatment.