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人乳头瘤病毒(HPV)中的16、18型等参与某些会阴部肿瘤如宫颈癌的发病。已知两种病毒E_1、E_2蛋白是病毒DNA复制所必需,本实验旨在研究参与病毒复制的细胞成分。作者用酵母双杂交系统筛选HeLa细胞cDNA文库中能与HPV-18 E_1相互作用的蛋白质,得到能编码Inil/hSNF5蛋白质的阳
Types 16 and 18 of human papillomavirus (HPV) are involved in the pathogenesis of certain perineal tumors such as cervical cancer. It is known that two viruses E_1 and E_2 proteins are necessary for viral DNA replication. This experiment aims to study the cellular components involved in virus replication. The authors used yeast two-hybrid system to screen HeLa cell cDNA library can interact with HPV-18E_1 protein, get coding for Inil / hSNF5 protein