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目的:调查庚型肝炎的流行病学及临床特点。方法:28例患者系我院住院病人,男16例,女12例,年龄23～69岁,其中急性肝炎8例,慢性肝炎轻度4例,慢性肝炎中度4例,慢性重型肝炎3例,活动性肝硬变9例;检测患者HGV-RNA采用RT-PCR法。结果:28例患者中有输血史者15例(53.6%),有静脉注射毒品史者1例(3.6%),不明原因者12例(42.6%);临床症状以纳差(100%),乏力(92.9%),尿色加深(75%)及恶心(53.6%)为主;病毒标志物检洲单纯庚型肝炎病毒感染4例(14.3%),乙、庚重叠感染13例(46.4%),丙、庚重叠感染6例(21.4%),乙、丙、庚重叠感染3例(10.7%);肝功能检测:TBil:45.08±22.48μmol/L,ALT 318.64±359.95U/L;纤维化指标:HA 515.39±800.79μg/L,LN 323±578.13μg/L,PCⅢ151.71±47.34μg/L,C Ⅳ 67.35±15.27ng//L。结论:①HGV主要经输血途径传播。同时存在其他肠道外途径传播如静脉注射毒品等。②HGV可引起急性、慢性、重型肝炎、肝硬变,易复发,易致慢性化。③HGV可与HGV和/或HCV同时或重叠感染。④HGV一般临床症状及肝功能损害较轻。
Objective: To investigate the epidemiology and clinical features of hepatitis G Methods: 28 patients were hospitalized in our hospital, 16 males and 12 females, aged 23 to 69 years, of which 8 cases of acute hepatitis, mild chronic hepatitis in 4 cases, moderate chronic hepatitis in 4 cases, 3 cases of chronic severe hepatitis , Active cirrhosis in 9 cases; detection of HGV-RNA using RT-PCR method. Results: There were 15 cases (53.6%) with transfusion history in 28 cases, 1 case (3.6%) with intravenous drug history and 12 cases (42.6%) with unknown cause. The clinical symptoms included anorexia (100%), (92.9%), deepened urine color (75%) and nausea (53.6%) were the main symptoms of hepatitis B virus infection. Among them, 4 cases (14.3%) had hepatitis G virus infection and 13 cases (46.4% ), C and C overlap infection in 6 cases (21.4%), B, C and C overlapping infection in 3 cases (10.7%); liver function test: TBil: 45.08 ± 22.48μmol / L, ALT 318.64 ± 359.95U / L; The indexes: HA 515.39 ± 800.79μg / L, LN 323 ± 578.13μg / L, PCⅢ151.71 ± 47.34μg / L, C Ⅳ 67.35 ± 15.27ng / L. Conclusion: ①HVV is mainly transmitted by blood transfusion. At the same time there are other routes of parenteral transmission such as intravenous drugs. HGV can cause acute, chronic, severe hepatitis, cirrhosis, easy to relapse, easy to cause chronic. HGV can be infected with HGV and / or HCV simultaneously or overlappingly. ④HVV general clinical symptoms and less damage to liver function.