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目的探讨内源性一氧化氮（ＮＯ）与肝硬化低氧血症的关系方法采用改良的Ｇｒｉｅｅｓｓ比色法测定６９例肝硬化患者及２０例正常对照者血清ＮＯ代谢产物ＮＯ_２~－／ＮＯ_３~－水平；血气分析仪测定动脉血氧分压．结果６９例肝硬化患者血清ＮＯ_２~－／ＮＯ_３~－水平为（３２．４±２６．７）μｍｏｌ／Ｌ，明显高于对照组的（６．２±１．９）μｍｏｌ／Ｌ两组对比差异显著（ｐ＜０．０１）肝硬化低氧血症的发生率为３３／６９（４７．８％）．肝硬化低氧血症组血清ＮＯ_２~－／ＮＯ_３~－水平为（４５．２±２８．７）μｍｏｌ／Ｌ，肝硬化无低氧血症组血清 ＮＯ_２~－／ＮＯ_３~－水平为（１８．０±１４．４）μｍｏｌ／Ｌ，两组对比差异显著（μ＜０．００１）．血清ＮＯ_２~－／ＮＯ_３~－水平随着肝功能 Ｃｈｉｌｄ－Ｐｕｇｈ分级的升高而升高Ａ、Ｂ、Ｃ级分别为（１４．４±１０．５）μｍｏｌ／Ｌ、 （２７．７±２１．１）μｍｏｌ／Ｌ、（５１．６±２９．７）μｍｏｌ／Ｌ、Ａ比 Ｂ级、Ｂ比Ｃ级均有显著性差异（ｐ＜０．０５，ｐ＜０．０１）．血氧分压则随着 Ｃｈｉｌｄ－ Ｐｕｇｈ分级的升高而降低Ａ、Ｂ、Ｃ级分别为（１２．７±２．０）ｋＰａ、（１０．９±２．４）ｋＰａ、（９．３?
Objective To investigate the relationship between endogenous nitric oxide (NO) and cirrhosis and hypoxemia.METHODS The serum levels of NO 2 ~ - / NO 3 ~ + in serum of 69 cirrhotic patients and 20 normal controls were measured by modified Grieess colorimetry - level; blood gas analyzer to measure arterial partial pressure of oxygen. Results The serum level of NO 2 - / NO 3 - in 69 cirrhotic patients was (32.4 ± 26.7) μmol / L, which was significantly higher than that in the control group (6.2 ± 1.9) μmol / L The difference was significant (p <0.01) The incidence of cirrhosis with hypoxemia was 33/69 (47.8%). The levels of NO 2 - / NO 3 - in serum of patients with cirrhosis and hypoxemia were (45.2 ± 28.7) μmol / L and the levels of NO 2 - / NO 3 - - in cirrhosis without hypoxemia were (18 .0 ± 14.4) μmol / L, the difference between the two groups was significant (μ <0.001). The level of serum NO 2 - / NO 3 - - increased with the increase of Child-Pugh liver function, the levels of A, B and C were (14.4 ± 10.5) μmol / L and (27.7 ± 21) .1) μmol / L, (51.6 ± 29.7) μmol / L respectively. There was a significant difference between A and B levels and C level (P <0.05, P <0.01). The partial pressure of oxygen decreased with the increase of Child-Pugh’s grading. The levels of A, B and C were (12.7 ± 2.0) kPa, (10.9 ± 2.4) kPa and (9.3 ?