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目的探讨HCV RNA PCR水平对丙型肝炎病毒(HCV)/人类免疫缺陷病毒(HIV)合并感染自然进程的影响。方法采用实时荧光定量PCR方法检测HCV RNA,比较初次就诊高效反转录病毒治疗(HAART)前的HCV/HIV合并感染(HCV/HIV组)、HCV单纯感染(HCV组)、HIV单纯感染(HIV组)患者的HCV RNA、HIV RNA、CD4+T淋巴细胞计数、天冬氨酸转氨酶(AST)、总胆红素(TBIL)、透明质酸酶(HA)、层粘连蛋白(LN)、甘胆酸(CG)、Ⅲ型胶原(PCⅢ)、Ⅳ型胶原(CⅣ)、年龄等指标。结果 HCV/HIV组与HCV组和HIV组CD4+T淋巴细胞计数分别为139.75±91.586、647.16±363.379、288.0±219.6个/微升(P<0.01)。与HCV组患者的发病年龄分别为37±15和52±13岁(P<0.01)。HCV RNA分别为6.0417±0.93524和5.2553±1.62773log/ml(P<0.05);CⅣ分别为105.30±24.630和95.41±52.889ng/ml(P<0.05);CG分别为1444.98±1721.597、139.00±165.640μg/ml(P<0.01);PCⅢ分别为285.52±244.558、159.82±86.928ng/ml(P<0.01);ALT分别为104.42±107.90、46.22±32.589U/L(P<0.01)。与HIV组HIV RNA分别为4.8±0.9和4.1±1.0log/ml(P<0.01)。结论 HCV/HIV合并感染可以加重和加快HCV、HIV疾病的自然进程。高水平的HCV RNA是HCV/HIV合并感染患者的HCV、HIV疾病自然进程的危险因素之一。
Objective To investigate the effect of HCV RNA PCR on the natural progression of co-infection with hepatitis C virus (HCV) / human immunodeficiency virus (HIV). Methods HCV RNA was detected by real-time fluorescence quantitative polymerase chain reaction (RT-PCR). HCV / HIV co-infection before infection (HCV / HIV group), HCV infection group HCV RNA, HIV RNA, CD4 + T lymphocyte count, aspartate aminotransferase (AST), total bilirubin (TBIL), hyaluronidase (HA), laminin (LN) Cholic acid (CG), type Ⅲ collagen (PC Ⅲ), type Ⅳ collagen (C Ⅳ), age and other indicators. Results The counts of CD4 + T lymphocytes in HCV / HIV group and HCV group were 139.75 ± 91.586, 647.16 ± 363.379 and 288.0 ± 219.6 / μl, respectively (P <0.01). Patients in the HCV group were 37 ± 15 years and 52 ± 13 years (P <0.01), respectively. HCV RNA were 6.0417 ± 0.93524 and 5.2553 ± 1.62773log / ml respectively (P <0.05); CⅣ were 105.30 ± 24.630 and 95.41 ± 52.889ng / ml respectively (P <0.05); CG were 1444.98 ± 1721.597 and 139.00 ± 165.640μg / ml (P <0.01); PCⅢ were 285.52 ± 244.558,159.82 ± 86.928ng / ml (P <0.01); ALT were 104.42 ± 107.90,46.22 ± 32.589U / L (P <0.01). HIV RNA in the HIV group was 4.8 ± 0.9 and 4.1 ± 1.0 log / ml, respectively (P <0.01). Conclusions HCV / HIV co-infection can exacerbate and accelerate the natural progression of HCV and HIV. High levels of HCV RNA are one of the risk factors for the natural progression of HCV and HIV disease in HCV / HIV co-infected patients.