论文部分内容阅读
目的探讨高危型人乳头瘤病毒(HR-HPV)测定与宫颈癌及其癌前病变的关系。方法选择首次诊断为宫颈癌及其癌前病变患者387例,在治疗前用第二代杂交捕获法(HC-Ⅱ)进行HR-HPV的测定,以病理学结果为确诊及分组标准,探讨HR-HPV阳性率、载量与宫颈病变之间的关系。结果HR-HPV阳性337例,阳性率为87.08%,阳性时病毒载量范围1.00～3221.87pg/ml。其中,低级别病变阳性率为75.41%,高级别病变阳性率为92.16%,宫颈癌的阳性率为100%。结论随着宫颈病变严重程度的增加,HR-HPV的检出率随之增加;但病毒载量与宫颈病变的严重程度无明显关系。
Objective To investigate the relationship between high-risk human papillomavirus (HR-HPV) and cervical cancer and its precancerous lesions. Methods 387 cases diagnosed as cervical cancer and precancerous lesion for the first time were selected. HR-HPV was detected by second-generation hybridization capture method (HC-Ⅱ) before treatment. The pathological findings were confirmed and the grouping criteria were evaluated. HR -HPV positive rate, the relationship between load and cervical lesions. Results The positive rate of HR-HPV was 337.08%. The positive rate of viral load ranged from 1.00 to 3221.87pg / ml. Among them, the positive rate of low-grade lesions was 75.41%, the high-grade lesions was 92.16%, the positive rate of cervical cancer was 100%. Conclusion As the severity of cervical lesions increases, the detection rate of HR-HPV increases. However, there is no significant relationship between the viral load and the severity of cervical lesions.