论文部分内容阅读
据报道,5-HT_3受体拮抗剂ICS 205-930对动物的胃平滑肌和增快胃排空速率具有很强的作用,但对人体则不同。作者用ICS205-930对患有原发神经性厌食症病人的胃排空情况和胃窦的收缩性进行了研究。13名女性患者,年龄中位数22岁,分为2组,随机进行交叉、双盲试验。静注0.15～0.18mg/kg ICS 205-930或安慰剂15min。随后服用一种含热量为1168千焦耳的同位素标记半固体的食物,对胃排空和胃窦收缩性用闪烁扫描记录50min。
It has been reported that the 5-HT_3 receptor antagonist ICS 205-930 has a strong effect on the gastric smooth muscle and the rate of gastric emptying in animals, but is different in humans. The authors used ICS205-930 to study gastric emptying and gastric contractility in patients with primary anorexia nervosa. Thirteen female patients, median age 22 years old, were divided into two groups, randomized crossover, double-blind trial. Intravenous 0.15 to 0.18 mg / kg ICS 205-930 or placebo for 15 min. Subsequent administration of an isotopically-labeled semisolid food containing 1168 kJ of heat was recorded by scintigraphy for gastric emptying and antral contractions for 50 min.