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Objectives: To identify the effect of vertical hepatitis C virus (HCV) infecti on or exposure on growth in childhood. Study design: Children (n = 1203) born to HCV-infected mothers were followed up from birth prospectively in centers of t he European Paediatric Hepatitis C virus Network. Z-scores compared height-and weight-for-age in HCV-infected and -uninfected children, adjusting for othe r factors using linear regression. We also quantified the effect of maternal chr onic infection with HCV on childhood growth. Results: There was no significant e ffect of vertical HCV infection on growth (height P = .223, weight P = .095) nor a significant effect of maternal chronic infection with HCV (height P = .733, w eight P = .274). Prematurity and maternal injecting drug use were associated wit h a significant reduction in height (P < .001) and weight (P < .001) in all HCV -exposed children. Conclusions: This population of HCV exposed infants has high er rates of maternal injecting drug use and prematurity than standard population s and so there are implications for growth of these children, but this is not a direct result of HCV infection or exposure to chronic maternal HCV infection.
Objectives: To identify the effect of vertical hepatitis C virus (HCV) infecti on or exposure on growth in childhood. Study design: Children (n = 1203) born to HCV-infected mothers were followed up from birth prospectively in centers of t he European Z-scores compared height-and weight-for-age in HCV-infected and -uninfected children, adjusting for othe r factors using linear regression. We also quantified the effect of maternal chr onic infection with HCV on childhood Results: There was no significant efect of vertical HCV infection on growth (height P = .223, weight P = .095) nor a significant effect of maternal chronic infection with HCV (height P = .733, w eight P = .274). Prematurity and maternal injecting drug use were associated wit ha significant reduction in height (P <.001) and weight (P <.001) in all HCV-exposed children. Conclusions: This population of HCV exposed infants has high er rates of maternal injecting drug use an d prematurity than standard population s and so there are both implications for growth of these children, but this is not a direct result of HCV infection or exposure to chronic maternal HCV infection.