棕色脂肪组织的非寒战性产热对于寒冷环境中体温的维持具有重要的作用。动物机体衰老后,棕色脂肪组织的产热能力降低,研究发现,动物衰老后,棕色脂肪组织萎缩,结合二磷酸鸟苷和解偶联蛋白含量下降,棕色脂肪组织中肾上腺素能β_3受体密度下降。此外,棕色脂肪组织的产热能力还受多种内分泌激素的影响,这些是非寒战产热能力在机体衰老时下降的可能机制。 Non-chilling fever of brown adipose tissue plays an important role in the maintenance of body temperature in cold environments. After aging, the production capacity of brown adipose tissue decreased. The study found that, after aging, the brown adipose tissue shrinks, the content of guanosine diphosphate and uncoupling protein decreases, and the adrenergic β_3 receptor density in brown adipose tissue decreases . In addition, the thermogenic capacity of brown adipose tissue is also affected by a variety of endocrine hormones, which are possible mechanisms by which non-chilling thermogenicity declines as the body ages.