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目的:研究芎归散超临界CO_2萃取物纳米结构脂质载体的制备。方法:采用微乳超声分散法制备芎归散超临界CO_2萃取物纳米结构脂质载体混悬液,以总苯酞的含量作为工艺研究中包封率的评价指标,以包封率为考察指标,采用正交试验筛选最佳处方,并考察其物理化学性质。结果:最佳处方为大豆卵磷脂-硬脂酸聚氢氧酯S-40-脂质载体(5:2:1),包封率为86.8%,所得纳米粒为类球形实体粒子,平均粒径92.6 nm,平均zeta电位-20.68 mV。结论:芎归散超临界CO_2萃取物纳米结构脂质载体的制备工艺基本可行。
Objective: To study the preparation of nanostructured lipid carrier of Xiongguisan supercritical carbon dioxide extract. Methods: The nanocosmic lipid carrier suspensions of Xiongguisan supercritical CO_2 extract were prepared by ultrasonic dispersion of microemulsions. The content of total phthalides was used as evaluation index for the entrapment efficiency in the process study. The entrapment efficiency was taken as the index , Using orthogonal test screening the best prescription, and examine its physicochemical properties. Results: The optimum formulation was soy lecithin-polyoxyester S-40 stearate (5: 2: 1) with the entrapment efficiency of 86.8%. The resulting nanoparticles were spheroidal solid particles with average particle size Diameter 92.6 nm, average zeta potential -20.68 mV. Conclusion: The preparation technology of Xiongguisan supercritical CO_2 extract nanostructured lipid carrier is feasible.