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目的探讨抗结核治疗所致肝功能损害患者的临床特点及治疗效果。方法选取2012年8月至2013年8月在灵宝市疾控中心接受抗结核治疗后出现肝功能损害的29例患者,对其临床资料进行回顾性分析,研究患者的治疗方法与治疗效果。结果合并有HBV感染、年龄≥60岁、每周饮酒量≥500 g的患者在抗结核治疗后发生肝功能损害的概率较高。29例抗结核治疗所致肝损害患者经1~2个月治疗和护理后肝功能恢复正常。结论抗结核治疗可对患者肝功能造成一定影响,当患者并发有HBV感染、饮酒过多、年龄较高时更易发病,及时发现、尽早治疗可促使患者肝功能恢复正常。
Objective To investigate the clinical features and therapeutic effects of patients with liver dysfunction caused by anti-TB therapy. Methods Twenty-nine patients with hepatic dysfunction after antituberculosis treatment at Lingbao CDC from August 2012 to August 2013 were retrospectively analyzed and their treatment and treatment effects were studied. Results Patients with HBV infection who were ≥60 years of age and drinking ≥500 g per week had a higher probability of developing hepatic impairment after anti-TB treatment. 29 cases of liver damage caused by anti-TB treatment of liver function returned to normal after 1 to 2 months of treatment and care. Conclusion Anti-TB treatment may have some impact on patients with liver function. When patients with HBV infection, excessive drinking, more likely to be older when the disease, and found that early treatment can prompt the return of liver function in patients with normal.