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目的研究浙江省宁波市HIV感染者和艾滋病人(HIV/AIDS)抗病毒治疗(HAART)效果和发生耐药情况。方法收集156例HIV-1型阳性病例血样,包括114例AIDS病人和42例未治疗感染者,检测CD4+T淋巴细胞数和HIV病毒载量,通过测序获得pol基因序列,经美国斯坦福大学HIV国际耐药数据库分析,获得毒株耐药情况。结果成功获得42例病例的pol序列;在HIV感染者中,HIV毒株对蛋白酶抑制剂分别有8例潜在耐药和2例中度耐药;在艾滋病人中,病毒载量低于最低检测限(50 IU/mL)的有100例,占87.7%;HIV毒株对核苷类和非核苷类抑制剂分别有4例和5例高度耐药;该人群的CD4+T淋巴细胞绝对数为14～1 060个/μL,平均为(314±28)个/μL。结论宁波市多数HIV感染者和艾滋病人对现有的抗病毒药物敏感,抗病毒治疗效果良好。
Objective To study the effect and drug resistance of anti-virus treatment (HAART) in HIV-infected and HIV-infected patients in Ningbo, Zhejiang Province. Methods The blood samples of 156 HIV-1 positive cases were collected, including 114 AIDS patients and 42 untreated patients. The numbers of CD4 + T lymphocytes and HIV viral load were detected. The pol gene sequences were obtained by sequencing. International drug resistance database analysis, access to drug resistant strains. RESULTS: Pol sequences of 42 cases were successfully obtained. Among HIV-infected patients, 8 strains were resistant to protease inhibitors and 2 were moderately resistant to HIV strains. In AIDS patients, the viral load was lower than the lowest level There were 100 cases (87.7%) of the limit (50 IU / mL); HIV strains were 4 and 5 highly resistant to nucleosides and non-nucleoside inhibitors respectively; the absolute number of CD4 + T lymphocytes 14 to 1060 cells / μL with an average of 314 ± 28 cells / μL. Conclusion Most HIV-infected and AIDS-infected people in Ningbo are sensitive to the existing antiviral drugs and the antiviral therapy is effective.