哮喘患者呼出气中内源性一氧化氮(NO)的含量增加,且与疾病的严重度相关。病毒感染可导致哮喘病情加重、短暂性的气道反应性增高和前炎症细胞因子产生增加,而后者可诱导上皮细胞和几种炎症细胞中诱导性NO合酶(iNOS)的表达,使得NO水平升高。作者在实验性鼻病毒16(RV16)感染的哮喘患者中探 In asthmatic patients, the content of endogenous nitric oxide (NO) is increased in exhaled air and is related to the severity of the disease. Infection with the virus can result in increased asthma, transient airway hyperresponsiveness, and increased pro-inflammatory cytokine production, which in turn induces the expression of inducible NO synthase (iNOS) in epithelial cells and several inflammatory cells such that NO levels Rise. The authors probed into asthma patients infected with experimental rhinovirus 16 (RV16)