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目的 探讨鼻咽癌病人机体的免疫状态及不同发展阶段的免疫状况 ,以求对病人的预后判断有一定帮助。方法 采用放射免疫扩散法和碱性磷酸酶—抗碱性磷酸酶法 ,对 35例鼻咽癌患者的免疫功能进行检测。取同期健康体检者 4 0例为对照组。结果 鼻咽癌组CD3+、CD4 +细胞和CD4 +/CD8+明显低于对照组 ( P <0 .0 1) ,IgM、IgG、IgA较对照组偏低 ,但无显著性差异 ( P >0 .0 5) ;随病变发展CD3+、CD4 +细胞和CD4 +/CD8+逐渐降低。结论 检测鼻咽癌患者血液中CD3+、CD4 +、CD4 +/CD8+对预后判断有一定的指导意义。
Objective To investigate the immune status of patients with nasopharyngeal carcinoma and immune status in different stages of development in order to determine the prognosis of patients to some extent. Methods Radioimmunoassay and alkaline phosphatase - alkaline phosphatase were used to detect the immune function of 35 patients with nasopharyngeal carcinoma. Take the same period of physical examination 40 cases as control group. Results The levels of CD3 +, CD4 + cells and CD4 + / CD8 + in nasopharyngeal carcinoma group were significantly lower than those in control group (P <0.01). The levels of IgM, IgG and IgA in nasopharyngeal carcinoma were lower than those in control group (P> 0.05). 0 5). With the development of CD3 +, CD4 + cells and CD4 + / CD8 + gradually decreased. Conclusion The detection of CD3 +, CD4 +, CD4 + / CD8 + in the blood of patients with nasopharyngeal carcinoma has some guiding significance.