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有关药物引起的粒细胞减少症的文献大多着重评论药物方面,几乎没有描述其口腔内的表现。本文报告一例粒细胞缺乏症引起典型的牙龈坏死的病例。患者女性,47岁,有长期春季花粉过敏病史。本次患病,流涕、喷嚏、咽部不适几天后出现发热与咽痛。给予头孢霉素和安乃近、消炎痛后仍不退热。施用消炎痛控制剂后不久退热,但很快又出现寒颤、恶心、呕吐。继而意识不清。病后第6天查白细胞700,中性粒细胞2%,最低白细胞计数降至400。停药后白细胞迅速上升至2300,3800,随着全身情况的改善,口腔症状开始明显。牙龈剧痛不能进食,进而上下颌龈边缘坏死,上面覆盖黄白色膜,腭部见很多白色斑块,涂片显示有霉
The literature on drug-induced neutropenia mostly focuses on the review of drugs, with little description of its oral performance. This article reports a case of necrosis of the gingiva caused by agranulocytosis. The female patient, 47 years old, had a long history of spring pollen allergy. The illness, fever, sore throat and sore throat, sneezing, throat discomfort after a few days. After giving cephalosporin and metamizole, indomethacin is still not hot. The fever was relieved soon after the indomethacin control agent was administered, but chills, nausea, and vomiting soon followed. Then it became unclear. On the 6th day after the disease, white blood cells were examined at 700 and neutrophils were 2%. The minimum white blood cell count was reduced to 400. After the discontinuation of the drug, the leukocytes rapidly rose to 2300,3800. With the improvement of the general condition, the oral symptoms began to become apparent. Gingival pain can not eat, and then the edge of upper and lower jaws necrosis, covering the yellow and white film, see many white plaques in the ankle, smears show mildew