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目的从血清水平探讨干扰素调节因子4(interferon regulatory factor 4,IRF4)与系统性红斑狼疮(systemic lupus erythematosus,SLE)的相关性。方法采用酶联免疫吸附试验(enzyme-linked immunosorbent assay,ELISA)分别检测90例SLE病人与90例对照血清IRF4表达水平,并结合问卷调查资料进行统计分析。结果 SLE患者与对照组,狼疮肾炎组与非肾炎组,疾病活动期与稳定期患者之间血清IRF4水平差异均无统计学意义(均有P>0.05),在SLE患者中,血清IRF4水平与疾病活动性指数评分之间也均无相关性,但血清IRF4水平在低补体(C3降低)阳性组和阴性组之间差异有统计学意义(Z=-3.14,P=0.002),其他实验室指标阳性组与阴性组血清IRF4水平差异未发现统计学意义。结论本实验从血清水平方面未发现IRF4与SLE发病存在相关性,以后研究中可以从其他方面来验证二者之间的关系,本实验也为研究SLE发病机制提供了新的思路。
Objective To explore the correlation between interferon regulatory factor 4 (IRF4) and systemic lupus erythematosus (SLE) from the serum level. Methods Serum levels of IRF4 in 90 patients with SLE and 90 controls were detected by enzyme-linked immunosorbent assay (ELISA), and statistical analysis was made based on questionnaire data. Results There was no significant difference in serum IRF4 levels between SLE patients and control group, lupus nephritis group and non-nephritis group, disease active stage and stable stage patients (all P> 0.05). In SLE patients, There was no correlation between disease activity index scores, but the level of serum IRF4 was significant difference between low and low complement C3 patients (Z = -3.14, P = 0.002). Other laboratories No significant difference was found in serum IRF4 levels between the positive and negative indexes. Conclusions In this study, we found no correlation between IRF4 and SLE in terms of serum levels. We can verify the relationship between IRF4 and SLE in other aspects in future, and provide new ideas for studying the pathogenesis of SLE.