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目的：评价局部动脉内溶栓和经皮腔内血管成形术（ＰＴＡ）结合在治疗急性大脑中动脉闭塞中的应用。方法：７例急性大脑中动脉闭塞用局部动脉内灌注ｔ－ＰＡ溶栓，６例Ｍ１段同时存在狭窄，用ＰＴＡ成功消除；所有病例均在发病６小时内开始治疗。结果：７例均获得闭塞动脉完全再通，６例Ｍ１段狭窄用ＰＴＡ消除，５例偏瘫完全恢复，１例有脑出血并发症。结论：局部动脉内溶栓和ＰＴＡ结合可能是治疗急性大脑中动脉闭塞的有效方法。
OBJECTIVE: To evaluate the use of local intra-arterial thrombolysis and percutaneous transluminal angioplasty (PTA) in the treatment of acute middle cerebral artery occlusion. Methods: Seven patients with acute middle cerebral artery occlusion were treated with local arterial infusion of t-PA thrombolysis. Six patients with M1 segment stenosis were successfully treated with PTA. All patients started treatment within 6 hours after onset. Results: All of the 7 cases received complete recanalization of the occluded artery. Six cases of M1 stenosis were eliminated by PTA. Five cases of hemiplegia were completely recovered and one case had complications of intracerebral hemorrhage. Conclusion: Local intra-arterial thrombolysis combined with PTA may be an effective method for the treatment of acute middle cerebral artery occlusion.