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目的 探讨骨肉瘤中尿激酶型纤溶酶原激活物(u PA)和基质金属蛋白酶9 (MMP 9)的表达与其复发、转移的关系。方法 采用免疫组织化学方法对46例骨肉瘤标本的u PA及MMP 9 表达进行检测,11 例骨软骨瘤作为对照。结果 u PA及MMP 9 在骨肉瘤中的阳性表达率分别为52.2 %和76.1%,骨肉瘤组织与骨软骨瘤组织间存在显著性升高(P<0.05);复发组与转移组的u PA表达有显著性升高(P<0.05);u PA、MMP 9的表达与骨肉瘤病理分级呈正相关,且u PA和MMP 9间表达呈正相关。结论 u PA和MMP 9共同促进骨肉瘤肿瘤细胞的生长和侵袭,有助于判断骨肉瘤预后。
Objective To investigate the relationship between the expression of uPA and MMP 9 and the recurrence and metastasis of osteosarcoma. Methods The expression of u PA and MMP 9 in 46 osteosarcoma specimens was detected by immunohistochemical method, and 11 osteochondroma as control. Results The positive rates of u PA and MMP 9 in osteosarcoma were 52.2% and 76.1%, respectively. There was a significant increase in osteosarcoma and osteochondroma (P <0.05). The u PA (P <0.05). The expression of uPA and MMP 9 was positively correlated with the pathological grade of osteosarcoma, and the expression of uPA and MMP 9 was positively correlated. Conclusion Both uPA and MMP-9 can promote the growth and invasion of osteosarcoma tumor cells and help to determine the prognosis of osteosarcoma.