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目的探讨金天格胶囊对非透析期肾性骨病患者钙磷代谢的影响。方法选择非透析期肾性骨病患者60例,随机分为治疗组和对照组,每组30例。两组均予优质低蛋白饮食、α-酮酸、降压、降脂等常规治疗,治疗组同时加用金天格胶囊。两组疗程均为6个月,分别于治疗前、治疗3个月和治疗后检测患者血清钙(Ca)、磷(P)、甲状旁腺激素(PTH)、碱性磷酸酶(ALP)、尿素氮(BUN)、肌酐(Scr)、尿酸(UA)水平。结果两组患者在治疗3个月和治疗后血清P、PTH、ALP、BUN、Scr、UA水平较治疗前明显降低(P<0.05),Ca水平升高(P<0.05)。治疗组在治疗后,BUN、Scr、UA水平明显低于对照组(P<0.05);在治疗3个月和治疗后,血清Ca水平升高以及血清P、PTH、ALP水平降低均较对照组明显(P<0.05)。结论金天格胶囊能有效纠正非透析期肾性骨病患者的钙磷代谢紊乱,抑制继发性PTH、ALP的分泌,并具有一定的肾脏保护作用。
Objective To investigate the effects of Jintiange capsule on calcium and phosphorus metabolism in non-dialysis renal osteodystrophy patients. Methods Sixty non-dialysis renal osteodystrophy patients were randomly divided into treatment group and control group, with 30 cases in each group. Both groups were given high-quality low-protein diet, α-keto acid, antihypertensive, lipid-lowering and other conventional treatment, the treatment group also added Jin Tiange capsule. The two groups were treated for 6 months before treatment, 3 months after treatment and after treatment, respectively. Serum Ca, P, PTH, ALP, BUN, Scr and UA. Results The levels of serum P, PTH, ALP, BUN, Scr and UA in the two groups were significantly decreased (P <0.05) and Ca increased after 3 months of treatment and before treatment (P <0.05). The levels of BUN, Scr and UA in the treatment group were significantly lower than those in the control group (P <0.05). After 3 months of treatment and after treatment, the level of serum Ca and the levels of serum P, PTH and ALP in the treatment group were lower than those in the control group Obviously (P <0.05). Conclusion Jintiange Capsule can effectively correct the disorders of calcium and phosphorus metabolism, inhibit the secretion of secondary PTH and ALP in non-dialysis patients with renal osteodystrophy and has certain renal protective effect.