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孤立性收缩压升高(ISH)可由多种因素引起。几项研究表明,冠心病、心力衰竭以及中风的发病率增加,均与持续的 ISH 相关。治疗老年 ISH 能否预防或降低心血管病的发病率和死亡率均未被阐明。作者采用前瞻、随机多中心及双盲研究,评价柳胺苄心定(Labetalol)对60岁以上老年 ISH 患者的疗效。病人和方法研究对象为133例 ISH 患者,年龄≥60岁。立位舒张压<95mmHg,收缩压≥160mmHg。先作安慰剂对照,为期4周,测得基础血压。
Isolated systolic blood pressure (ISH) can be caused by many factors. Several studies have shown an increased incidence of coronary heart disease, heart failure, and stroke, all associated with sustained ISH. Whether or not treatment of elderly ISH can prevent or reduce cardiovascular morbidity and mortality has not been elucidated. The prospective, randomized, multicenter and double-blind study evaluated the efficacy of Labetalol in elderly patients over the age of 60 with ISH. Patients and Methods Subjects were 133 ISH patients aged ≥60 years. Standing diastolic blood pressure <95mmHg, systolic blood pressure ≥ 160mmHg. Placebo-controlled, for a period of 4 weeks, measured basal blood pressure.