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目的探讨肥胖超重青少年患者血清脂联素等生化指标水平的变化及与颈动脉内中膜厚度的关系,为预防肥胖相关的心血管疾病的发生提供依据。方法测定40名肥胖青少年、37名超重青少年和42名体重正常青少年血清脂联素水平及颈动脉内中膜厚度,分析3组间的水平变化、分析两者间的相互关系。结果肥胖组血浆脂联素水平与超重组、正常对照组比较,明显低于对照组,差异有统计学意义(P<0.05)。肥胖组颈动脉内中膜厚度与超重组、正常对照组比较,差异有统计学意义(P<0.05)。颈动脉内-中膜厚度与脂联素水平呈负相关。结论肥胖青少年血清脂联素水平明显下降,颈动脉内膜厚度增厚,肥胖青少年存在着血管内皮功能障碍,动脉顺应性功能下降。
Objective To investigate the changes of serum adiponectin and other biochemical markers in obese overweight adolescents and its relationship with the intima - media thickness of carotid artery in order to provide a basis for preventing the occurrence of obesity related cardiovascular diseases. Methods The levels of serum adiponectin and carotid artery intima-media thickness were measured in 40 obese adolescents, 37 overweight adolescents and 42 normal-weight adolescents. The level changes of the three groups were analyzed, and the relationship between the two groups was analyzed. Results The level of plasma adiponectin in obesity group was significantly lower than that in control group (P <0.05). There was significant difference in carotid intima-media thickness between the obese group and the overweight group and the normal control group (P <0.05). Intima-media thickness of carotid artery was negatively correlated with adiponectin level. Conclusion The level of serum adiponectin in obese adolescents is obviously decreased, the carotid intima-media thickness is thickened, obese adolescents have vascular endothelial dysfunction and arterial compliance decreases.