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目的探讨临产高危妊娠患者凝血四项和D-二聚体(D-D)水平变化。方法选取2013年7月-2014年2月本院收治的临产孕妇240例,参照上海市高危妊娠评分标准,分为A级组57例,B级组70例,C级组69例,正常妊娠组44例。检测凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、凝血酶时间(TT)、纤维蛋白原(FIB)和D-D,与未孕健康育龄期女性24例正常对照比较分析。结果各妊娠组PT、APTT值与未孕组差异无统计学意义(P>0.05)。TT值仅A级组显著低于未孕组(P<0.05)。各妊娠组FIB和D-D水平均显著高于未孕组(P<0.01),但C级组FIB水平显著低于正常妊娠组(P<0.05),D-D水平随高危妊娠程度加重显著升高(P<0.01)。结论凝血常规并不能及时敏感地提示机体的高凝状态,FIB和D-D检测在高危妊娠患者中更应重视。
Objective To investigate the changes of coagulation level and D-dimer (D-D) levels in patients with high-risk pregnancy. Methods From July 2013 to February 2014, 240 pregnant women were enrolled in our hospital. According to the high-risk pregnancy grading standards in Shanghai, 57 cases were divided into A group (57 cases), B group (70 cases), C group (69 cases), normal pregnancy Group of 44 cases. The prothrombin time (PT), activated partial thromboplastin time (APTT), thrombin time (TT), fibrinogen (FIB) and D-D were measured and compared with 24 healthy controls. Results There was no significant difference in PT and APTT between pregnancy group and non-pregnant group (P> 0.05). The TT value was only significantly lower in the A-level group than in the non-pregnant group (P <0.05). The levels of FIB and DD in each pregnancy group were significantly higher than those in non-pregnant group (P <0.01), but the levels of FIB in C group were significantly lower than those in normal pregnancy group (P <0.05) <0.01). Conclusion Coagulation routine does not promptly prompt the body hypercoagulable state, FIB and D-D detection in patients with high risk should pay more attention.