糖尿病病程在10年以上时,患者常发生明显的临床糖尿病神经病变。其发生风险与糖尿病的病程、血糖控制不佳等密切相关。糖尿病神经病变可累及中枢神经及周围神经(包括自主神经),其中最常见的是糖尿病周围神经病变(diabetic peripheral neuropathy,DPN)。糖尿病周围神经病变是指在排除其他病因的情况下,糖尿病患者出现的周围神经功能障碍相关的症状和(或)体征。目前糖尿病神经病变的常规治疗包括对症治疗和对 Patients with diabetes often develop significant clinical diabetic neuropathy when their duration of diabetes is over 10 years. The risk is closely related to the course of diabetes and poor glycemic control. Diabetic neuropathy can affect the central nervous and peripheral nerves (including autonomic nerve), the most common of which is diabetic peripheral neuropathy (DPN). Diabetic peripheral neuropathy refers to the symptoms and / or signs associated with peripheral neuropathy occurring in diabetic patients excluding other causes. The current routine treatment of diabetic neuropathy includes symptomatic treatment and right