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恶性疟原虫的抗氯喹株从20世纪60年代初首次报告后,现在亚洲的许多地区和南美都有发现。抗性的流行和程度在所有受影响的地区尚在增长,这是抗疟规划的一个严重障碍。由于替代的药物更昂贵,而且往往使用更麻烦。因而必须在制定用药标准化方针以阻止抗性株散布方面,作不懈的努力。本文考虑了抗药性的遗传学和流行学,并着重于有关控制抗性的一些问题。还叙述了世界卫生组织近来制定的监视抗药性流行和程度及有效对策的全球规划。
The chloroquine resistant Plasmodium falciparum strain was first reported in the early 1960s and is now found in many parts of Asia and in South America. The prevalence and extent of resistance is still growing in all affected areas, a serious obstacle to the antimalarial program. Because alternative medicines are more expensive and often more cumbersome to use. Therefore, we must make unremitting efforts in formulating a standardized guideline for drug use to prevent the spread of resistant strains. This article considers resistance genetics and epidemiology and focuses on some issues related to controlling resistance. The global plan recently developed by the World Health Organization to monitor the prevalence and extent of drug resistance and respond effectively has also been described.