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目的:探讨肾炎康复片对慢性肾小球肾炎患者血清粘连蛋白(fibronectin,FN)、白介素-2(interleukin-2,IL-2)及胱抑素C水平影响。方法:收集我院慢性肾小球肾炎患者80例,随机分为实验组和对照组。两组患者均予低盐优质蛋白饮食、控制血压、预防感染等常规治疗。对照组予以贝那普利治疗,实验组在对照组基础上加用肾炎康复片。两组患者分别于治疗前、后各进行一次血清FN、IL-2、胱抑素C水平测定;血压,肾功能血清肌酐(SCr)、尿素氮(BUN),24 h尿蛋白测定。结果:治疗后两组患者血清FN、IL-2水平均上升,胱抑素C水平均下降(P<0.05),与对照组比较,实验组三项指标均变化更明显(P<0.05);治疗后两组患者血压、血清肌酐、尿素氮、24 h尿蛋白水平均下降(P<0.05),与对照组比较,实验组四项指标均较低(P<0.05)。结论:肾炎康复片可更显著升高慢性肾小球肾炎患者血清FN、IL-2水平,降低胱抑素C水平,对患者血压控制,肾功能修复及减少尿蛋白有重要作用。
Objective: To investigate the effects of Shenyinkang Tablets on the levels of fibronectin (FN), interleukin-2 (IL-2) and cystatin C in patients with chronic glomerulonephritis. Methods: 80 patients with chronic glomerulonephritis in our hospital were randomly divided into experimental group and control group. Both groups were given low-salt high-quality protein diet, blood pressure control, prevention of infection and other conventional treatment. The control group was treated with benazepril, the experimental group in the control group based on the use of nephritis rehabilitation tablets. Serum levels of FN, IL-2 and Cystatin C were measured in both groups before and after treatment. Blood pressure, serum creatinine (SCr), blood urea nitrogen (BUN) and 24 h urinary protein were measured. Results: The levels of serum FN and IL - 2 in both groups increased after treatment, and the levels of cystatin C decreased (P <0.05). Compared with the control group, the changes of three indexes in the experimental group were more obvious (P <0.05). After treatment, blood pressure, serum creatinine, urea nitrogen and 24 h urinary protein levels decreased in both groups (P <0.05). Compared with the control group, the four indexes in the experimental group were lower (P <0.05). Conclusion: Shenyankang tablets can significantly increase serum FN, IL-2 levels and reduce the level of cystatin C in patients with chronic glomerulonephritis, and play an important role in the control of blood pressure, renal function, and proteinuria in patients with chronic glomerulonephritis.