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白细胞介素12(IL-12)对T细胞及NK/LAK细胞的活化有多种促进作用,可单独或协同IL-12诱导lFN-γ产生,从而间接发挥抗肿瘤作用.IL-12可促进Thl细胞的分化和增殖,IL-4可以促进Th2细胞的应答,两者之间的相互作用,对免疫平衡的调节具有重要意义.肿瘤细胞的诱导分化治疗,是肿瘤基础和临床研究的重点之一.关于IL-12直接作用于肿瘤细胞,诱导其分化的研究,尚未见文献报道.为进一步探讨IL-12的抗肿瘤作用机制,寻找新的诱导分化疗法,以小
Interleukin 12 (IL-12) has various promoting effects on the activation of T cells and NK/LAK cells, which can induce lFN-γ production by IL-12 alone or synergistically, thus indirectly exerting antitumor effects. IL-12 can promote The differentiation and proliferation of Thl cells, IL-4 can promote the response of Th2 cells, and the interaction between the two is important for the regulation of immune balance. The induction and differentiation treatment of tumor cells is the focus of basic and clinical research on tumors. A. Studies on the direct action of IL-12 on tumor cells and their induction of differentiation have not been reported in the literature. To further explore the anti-tumor mechanism of IL-12, we are looking for new induction differentiation therapy.