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为评价四乙酰基六氮杂异伍兹烷(TAIW)的亚急性经口毒性,将40只健康SPF级SD大鼠按体重随机分为对照组(3%淀粉溶液)和250、500、1 000 mg/kg TAIW染毒组,每组10只,雌雄各半。采用灌胃方式进行染毒,连续染毒28 d。结果显示,与对照组比较,1 000 mg/kg TAIW染毒组雄性大鼠中性粒细胞数升高,凝血酶时间延长;500、1 000 mg/kg TAIW染毒组雄性大鼠血中巨大不成熟细胞百分比降低;500、1 000 mg/kg TAIW染毒组雌性大鼠红细胞体积、血小板体积、血小板分布宽度和Na+浓度均降低,1 000 mg/kg TAIW染毒组雌性大鼠Cl-浓度升高,250、500 mg/kg TAIW染毒组雌性大鼠凝血酶时间延长(P<0.05,P<0.01)。对照组和各剂量TAIW染毒组大鼠脏器未见明显病理学改变。提示TAIW对大鼠血液系统和凝血系统有损伤作用。
To assess the subacute oral toxicity of tetraacetylhexaazaisowurtzitane (TAIW), 40 healthy SPF SD rats were randomly divided into control (3% starch solution) and 250, 500, 1 000 mg / kg TAIW exposure group, 10 in each group, male and female. Gavage by way of exposure, continuous exposure 28 d. The results showed that compared with the control group, the number of neutrophils in the 1 000 mg / kg TAIW-treated male rats increased and the thrombin time prolonged. In the 500 and 1000 mg / kg TAIW-treated male rats, The percentage of immature cells decreased; the erythrocyte volume, the platelet volume, the platelet distribution width and the Na + concentration of the female rats in the 500 and 1 000 mg / kg TAIW exposure groups were decreased. The Cl- concentrations in the female rats in the 1 000 mg / kg TAIW exposure group (P <0.05, P <0.01). The thrombin time was prolonged in 250 and 500 mg / kg TAIW exposure groups. No significant pathological changes were observed in the control and TAIW-treated rats. Tip TAIW rat blood system and coagulation system injury.