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25例眼-口-生殖器三联症患者,7例有中枢神经系统损害。其中男2例,女5例。年龄19～48岁。从起病至中枢神经系统损害的时间为0～3年,平均1.3年。全部7例于中枢神经系统损害时或损害前有发热及头痛。损害形式以皮质脊髓束为最常见:偏瘫3例,四肢瘫2例。小脑性共济失调4例,假性球麻痹3例,短暂性眼肌麻痹3例。中枢神经系统的症状常在伴发的口疮病、滑膜炎或发热时恶化。7例腰脑脊液均有异常:白细胞6～490个/立方毫米(平均117个),淋巴细胞增多为常见,15～100％(平均74％)。在急性脑炎发作时多形核白细胞暂时增多。脑脊液的总蛋白31～96毫克％(平均55毫克),γ球蛋白浓度正常,低于总蛋白的15％(检查6例)。脑脊液和口腔-生殖器溃疡的细菌培养、霉菌及病毒阴性。
25 cases of eye - mouth - genital triad patients, 7 cases of central nervous system damage. There are 2 males and 5 females. Age 19 ~ 48 years old. From the onset to the central nervous system damage time is 0 to 3 years, an average of 1.3 years. All 7 patients had fever and headache before or during damage to the central nervous system. Damage to the corticospinal tract as the most common form: hemiplegia in 3 cases, quadriplegia in 2 cases. 4 cases of cerebellar ataxia, pseudobulbar palsy in 3 cases, transient ocular paralysis in 3 cases. The symptoms of the central nervous system often associated with aphthous sores, synovitis or fever worsened. Seven cases of lumbar and cerebrospinal fluid abnormalities: white blood cells 6 to 490 / mm3 (average 117), lymphocytosis is common, 15 to 100% (average 74%). Polymorphonuclear leukocytes temporarily increase during an episode of acute encephalitis. Cerebrospinal fluid total protein 31 ~ 96 mg% (average 55 mg), γ-globulin concentration normal, less than 15% of total protein (check 6 cases). Bacterial culture of cerebrospinal fluid and oral-genital ulcers, mold and virus negative.