【摘 要】
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目的 探讨血管生成对乳腺癌的预后价值 ,以及与p5 3和ER的关系 ;方法 利用免疫组化法 ,检测 5 9例乳腺癌的FⅧ ,p5 3的表达 ,采用计算机图像分析系统 ,检测肿瘤微血管面积(
【机 构】
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重庆医科大学附属第一医院普外科,重庆医科大学附属第一医院普外科,重庆医科大学附属第一医院普外科 重庆400016,重庆400016,重庆400016
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目的 探讨血管生成对乳腺癌的预后价值 ,以及与p5 3和ER的关系 ;方法 利用免疫组化法 ,检测 5 9例乳腺癌的FⅧ ,p5 3的表达 ,采用计算机图像分析系统 ,检测肿瘤微血管面积(MEA )。结果 ( 1)肿瘤越大 ,肿瘤分级越高 ,其MEA越高 (均为P <0 .0 5 ) ;( 2 )有腋淋巴结转移者的MEA明显高于无淋巴结转移者 (P <0 .0 5 ) ;( 3 )复发患者的MEA明显高于无复发者 (P <0 .0 1) ;( 4 )未发现MEA与 p5 3和ER有相关性。 结论 血管生成可作为乳腺癌一个独立的判断预后因子。
Objective To investigate the prognostic value of angiogenesis in breast cancer and its relationship with p5 3 and ER.Methods Immunohistochemistry was used to detect the expression of FⅧ and p5 3 in 59 cases of breast cancer.Using computerized image analysis system, Area (MEA). Results (1) The larger the tumor, the higher the tumor grade, the higher the MEA (all P <0.05). (2) The MEA in patients with axillary lymph node metastasis was significantly higher than those without lymph node metastasis (P <0. (3) The MEA of relapsed patients was significantly higher than that of patients without recurrence (P <0.01). (4) There was no correlation between MEA and p5 3 and ER. Conclusion Angiogenesis can be an independent prognostic factor for breast cancer.
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