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目的探讨血清尿酸(UA)、超敏C反应蛋白(hs-CRP)在HIE新生儿中的变化及其意义。方法选择2006年1月-2007年6月HIE新生儿36例为观察组。其中轻度14例,中度12例,重度10例。同期本院出生的健康新生儿24例为健康对照组。二组性别、年龄、胎龄、出生体质量等比较均无明显差异,具有可比性。二组新生儿均抽股静脉血4mL,分离血清,免疫比浊法测定其血清UA、hs-CRP水平。结果1.HIE患儿的急性期血清UA、hs-CRP水平分别为(419.78±85.58)μmol/L、(5.42±2.69)mg/L,明显高于健康对照组[(240.23±87.24)μmol/L、(2.58±0.89)mg/L](Pa<0.01),明显高于恢复期[(255.69±86.62)μmol/L,(3.21±1.27)mg/L](Pa>0.01);恢复期与健康对照组比较无显著性差异(Pa>0.05)。2.重度HIE组患儿血清UA、hs-CRP水平分别为(508.34±87.79)μmol/L、(6.87±2.78)mg/L,中度组分别为(410.21±85.02)μmol/L、(4.54±2.17)mg/L,均明显高于轻度组[(319.89±85.04)μmol/L、(3.34±1.89)mg/L](Pa<0.01),重度组显著高于中度组(Pa<0.05)。3.HIE组患儿急性期、恢复期的血清UA与hs-CRP呈显著正相关(r=0.851,0.832 Pa<0.05);HIE患儿重度组、中度组、轻度组血清UA与hs-CRP呈显著正相关(r=0.846,0.835,0.827 Pa<0.05)。结论血清UA与hs-CRP的动态变化具有协同性,且与HIE的病情相平行,可反映HIE患儿病情轻重程度,可作为判断HIE疗效和判定病情严重程度的实验室指标。
Objective To investigate the changes of serum uric acid (UA) and hs-CRP in neonates with HIE and its significance. Methods 36 neonates with HIE from January 2006 to June 2007 were selected as the observation group. Of which mild in 14 cases, moderate in 12 cases, severe in 10 cases. In the same period, 24 healthy newborns born in our hospital were healthy control group. Two groups of gender, age, gestational age, birth weight, etc. were no significant differences, comparable. Two groups of newborns were drawn 4mL venous blood, serum was separated, and the levels of serum UA and hs-CRP were measured by immunoturbidimetry. The levels of serum UA and hs-CRP in acute stage of HIE were (419.78 ± 85.58) μmol / L and (5.42 ± 2.69) mg / L, respectively, which were significantly higher than those in healthy control group [(240.23 ± 87.24) μmol / L, (2.58 ± 0.89) mg / L] (Pa <0.01), which were significantly higher than those in the recovery phase [(255.69 ± 86.62) μmol / L and (3.21 ± 1.27) mg / L] There was no significant difference between the healthy control group (Pa> 0.05). Serum levels of UA and hs-CRP were (508.34 ± 87.79) μmol / L and (6.87 ± 2.78) mg / L respectively in the severe HIE group and (410.21 ± 85.02) μmol / L and ± 2.17) mg / L were significantly higher in the severe group than in the mild group (P <0.01), and were significantly higher in the severe group than in the mild group (319.89 ± 85.04 μmol / L, 3.34 ± 1.89 mg / L, 0.05). There was a significant positive correlation between serum UA and hs-CRP in acute and convalescent phase of HIE group (r = 0.851,0.832 Pa <0.05). Serum UA and hs in severe, moderate and mild HIE group -CRP (r = 0.846,0.835,0.827 Pa <0.05). Conclusions The dynamic changes of serum UA and hs-CRP are synergistic. They are parallel with the HIE and reflect the severity of HIE. They can be used as laboratory indexes to judge the effect of HIE and determine the severity of HIE.