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越来越多的实验结果证实巨噬细胞集落刺激因子在动脉粥样硬化发生过程中的重要作用,为了探讨巨噬细胞集落刺激因子和活性氧与动脉粥样硬化之间的相互关系,观察了巨噬细胞集落刺激因子对培养的小鼠腹腔巨噬细胞抗氧化酶活性的影响。结果发现巨噬细胞集落刺激因子能使小鼠腹腔巨噬细胞谷胱甘肽过氧化物酶活性提高32%,超氧化物歧化酶的活性提高120%,并减轻叔丁基氢过氧化物促巨噬细胞源性泡沫细胞形成,以及提高巨噬细胞的生存数。此结果提示巨噬细胞集落刺激因子提高杭氧化酶活性的作用可能是其虽增加对氧化修饰低密度脂蛋白和胆固醇的摄入却能阻止泡沫细胞形成及动脉粥样硬化发生发展的原因之一。
More and more experimental results confirm the important role of macrophage colony-stimulating factor in the process of atherosclerosis. In order to investigate the correlation between macrophage colony stimulating factor and reactive oxygen species and atherosclerosis, Effect of Macrophage Colony Stimulating Factor on the Antioxidase Activity of Peritoneal Macrophages in Cultured Mice. The results showed that macrophage colony-stimulating factor increased glutathione peroxidase activity by 32%, superoxide dismutase activity increased by 120%, and alleviated the t-butyl hydroperoxide-induced macrophage Cell-derived foam cell formation, and increased macrophage survival. This result suggests that macrophage colony-stimulating factor may enhance the activity of COX, which may be one of the reasons that it can prevent the formation of foam cells and the development of atherosclerosis even though it increases the intake of oxidized low density lipoprotein and cholesterol .