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目的探讨高通量CRRT和血浆置换联合应用在治疗药物性肝衰竭中的临床疗效。方法对广西钦州市第一人民医院收治的50例药物性肝衰竭患者的治疗回顾性分析。治疗组26例在内科综合护肝治疗基础上同时给予高通量CRRT和血浆置换。对照组24例仅给予内科综合护肝治疗。结果治疗后治疗组较对照组明显改善(P<0.05),两组差异有统计学意义(P<0.05)。结论内科综合护肝治疗基础上及时联合应用高通量CRRT和血浆置换治疗药物性肝衰竭,可明显提高药物性肝衰竭的疗效。
Objective To investigate the clinical effects of high-throughput CRRT and plasma exchange in the treatment of drug-induced liver failure. Methods Retrospective analysis of 50 cases of drug-induced liver failure admitted to the First People’s Hospital of Qinzhou, Guangxi. In the treatment group, 26 cases were given high-throughput CRRT and plasma exchange on the basis of comprehensive internal medicine therapy. The control group, 24 cases were given medical comprehensive liver protection. Results After treatment, the treatment group was significantly improved compared with the control group (P <0.05), the difference between the two groups was statistically significant (P <0.05). Conclusion The combination of high-throughput CRRT and plasma exchange in the treatment of drug-induced liver failure can significantly improve the efficacy of drug-induced liver failure.