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目的:探讨ESWL联合坦索罗辛治疗输尿管结石并促进结石排出的有效性与安全性。方法:对80例单发输尿管下段结石患者在应用ESWL治疗后分组进行为期2周的临床观察,40例采用保守治疗(对照组),即每天饮水2 L,必要时采用非甾体类抗炎药物缓解症状;40例除采用保守治疗外,加用坦索罗辛0.4 mg,每天1次(治疗组)。结果:ESWL后2周,两组均行影像学检查。对照组排石率为47.5%(19/40),治疗组为77.5%(31/40)。2周内,两组发生肾绞痛分别为15%(6/40)和7.5%(3/40)。治疗组有2例发生轻微头晕乏力。结论:坦索罗辛可以显著提高ESWL后的结石排出率,减少发生肾绞痛机率,不良反应轻微,是输尿管下段结石ESWL后辅助排石的治疗方法之一。
Objective: To investigate the efficacy and safety of ESWL plus tamsulosin in the treatment of ureteral calculi and promote the removal of stones. Methods: Eighty patients with lower ureteral stones undergoing ESWL were divided into two groups for a period of 2 weeks. Forty patients underwent conservative treatment (control group), 2 L of drinking water per day. Non-steroidal anti-inflammatory Drugs to relieve symptoms; 40 patients with conservative treatment, plus tamsulosin 0.4 mg, 1 day (treatment group). Results: Two weeks after ESWL, imaging examination was performed in both groups. In the control group, the rate of stone removal was 47.5% (19/40) in the treatment group and 77.5% (31/40) in the treatment group. Within 2 weeks, renal colic were 15% (6/40) and 7.5% (3/40) in the two groups, respectively. Two patients in the treatment group had mild dizziness and fatigue. Conclusion: Tamsulosin can significantly improve the rate of stone excretion after ESWL, reduce the incidence of renal colic, and have mild adverse reactions. It is one of the treatment methods for anterograde paving stone after ESWL of lower ureteral calculi.