论文部分内容阅读
本研究采用Ｖｏｇｅｌ模型评价急性吗啡处理、经纳洛酮催瘾大鼠的焦虑症状，并对模型的可行性进行了考察。结果表明，Ｖｏｇｅｌ饮水模型能较好反映大鼠催促戒断后４８ｈｒ时的焦虑状态，５－ＨＴ受体激动剂丁螺环酮可明显缓解Ｖｏｇｅｌ模型中成瘾大鼠的焦虑症状。＊ｐ＜０．０１与生理盐水组比较ｐ＜０．０５与吗啡组比较研究结果表明，钠洛酮催瘾后，吗啡成瘾组大鼠的体重下降、腹泻等戒断症状非常明显，综合评分亦最高。抗焦虑剂丁螺环酮（剂量５ｍｇ。ｋｇ－１）对戒断综合征中的腹泻症状有一定抑制作用（排便量减少，ｐ＜０．０５）．而对体重下降等其他指标无明显作用。２．各组大鼠在Ｖｏｇｅｌ模型中的ＬＮ及ＳＮ结果表明，禁水４８小时后，吗啡组大鼠的饮水次数（ＬＮ）和被电击次数（ＳＮ）明显低于生理盐水组和丁螺环酮组（ｐ＜０．０１）。说明在戒断４８小时后，动物的焦虑症状明显。而丁螺环酮组大鼠的ＬＮ及ＳＮ明显高于戒断大鼠，与生理盐水组无差异，表明丁螺环酮有显著的抗焦虑作用。讨论Ｖｏｇｅｌ饮水模型是利用禁水动物烦渴心理和对饮水时受到的电刺激而产生的恐惧形成动物的矛盾冲突行为。以动物舔水次数和被电击次数作为焦虑指标。焦虑动物的ＬＮ和ＳＮ明显减少：抗焦虑药能增?
In this study, Vogel model was used to evaluate the acute morphine treatment, anxiety symptoms of naloxone-induced rats, and the feasibility of the model was investigated. The results showed that the Vogel drinking water model can better reflect the anxiety state at 48 hours after withdrawal of rats and the 5-HT receptor agonist buspirone can relieve the anxiety symptoms of the addicted rats in Vogel model. * P <0.01Compared with saline group, p <0.05Compared with morphine group, the results showed that the morphine addicted rats had weight loss and diarrhea and other withdrawal symptoms were obvious The highest score. Buspirone, an anti-anxiety agent (at a dose of 5 mg.kg-1), had some inhibition of diarrhea symptoms in the withdrawal syndrome (reduced bowel movements, p <0.05). And other indicators of weight loss and no significant role. 2. The results of LN and SN in Vogel model showed that the number of water intake (LN) and the number of electric shocks (SN) in morphine group were significantly lower than those in saline group and buspirone group (P <0.01). Description 48 hours after withdrawal, the animals have obvious symptoms of anxiety. While the buspirone group rats LN and SN were significantly higher than the withdrawal of rats, no difference with the saline group, indicating buspirone significant anti-anxiety effect. Discusses Vogel drinking water model is the contradictory behavior that takes advantage of the fear-provoking animals which are generated by the excitement of the thirst of the water-eating animals and the electrical stimulus when drinking water. Licking the number of animals and the number of shocks as an anxiety indicator. Anxious animals, LN and SN significantly reduced: Anxiolytics can increase?