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多器官功能障碍综合征（ MODS）是当今危重症医学研究的重点，因病死率极高，研究其发病机制是有效治疗的根本，建立可重复性经济标准的动物模型是研究的基础。国内外对 MODS的研究方向不同，所依据的模型制作原理也不尽相同，因此其动物模型的制作方法也有较大差别。该文对MODS的相关动物模型制作方法及优缺点予以综述，为相关实验研究提供参考。“,”Multiple organ dysfunction syndrome(MODS) is the focus of the critically ill study,due to the high mortality,the study of its pathogenesis is fundamental to find effective treatment and to establish repeat-able and economic standard animal model is the basis of the research.The direction of research on MODS is different at home and abroad,and the basis of the model making the models is not all the same,therefore the model making methods are varied considerably as well.Here is to make a review of the MODS animal model-ing approaches and their advantages and disadvantages,so as to provide a reference for the experiment and research.