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目的观察癫痫患者的免疫功能状态。方法检测了２８例癫痫患者外周血单个核细胞（ＰＢＭＣ）培养上清液的ＴＮＦα水平，测定了血清ｓＩＬ－２Ｒ，并与２５例对照组进行比较。结果癫痫患者ｓＩＬ－２Ｒ和ＴＮＦα显著高于对照组，其与病因、癫痫类型、服药及脑电图无关，但ＴＮＦα与病程有关。结论癫痫患者免疫功能低下，体内淋巴细胞处于活化状态。提示活化淋巴细胞分泌高水平的ＴＮＦα可能参与癫痫的发生发展
Objective To observe the immune status of patients with epilepsy. Methods The levels of TNFα in peripheral blood mononuclear cells (PBMCs) of 28 epilepsy patients were measured. Serum sIL-2R levels were measured and compared with 25 controls. Results The levels of sIL-2R and TNFα in patients with epilepsy were significantly higher than those in the control group. The levels of sIL-2R and TNFα in patients with epilepsy were not related to the etiology, type of epilepsy, medication and electroencephalogram. Conclusion Epilepsy patients with immune dysfunction, the body’s lymphocytes in an activated state. Tip activated lymphocytes secreting high levels of TNFα may be involved in the development of epilepsy